"Cady" (Lindsay Lohan) has spent much of her life being home schooled by her scientist parents in the African wilderness. Maybe that ought to have prepared her for her relocation to an American High School where the dog eat dog attitude is just as prevalent. She alights on the two school oddballs - "Janis" (Lizzy Caplan) and her "almost too gay to function" pal "Damian" (Daniel Franzese) who guide her through the tribes of people at the school. The ones to be avoided at all costs are the "Plastics" - vain and vacuous girls led by "Regina" (Rachel McAdams). When "Cady" is invited to join them f...