The science behind this may well be plausible - that cures for human ailments may well rest elsewhere in the animal kingdom. To that end Saffron Burrows ("Susan") enlists the help of millionaire philanthropist "Russell Franklin" (Samuel L. Jackson) to develop a cure for Alzheimer's using sharks captive in a converted offshore submarine refuelling base. When he arrives at the facility he meets the rather oddball crew including "Carter" (Thomas Jane") "Preacher" (LL Cool J) and "Jim" (Stellan Skarsgård) before quickly discovering that these genetically altered fish are tired of being the guinea-...